Treg and CTLA-4: Two intertwining pathways to immune tolerance
نویسندگان
چکیده
منابع مشابه
Treg and CTLA-4: Two intertwining pathways to immune tolerance
Both the CTLA-4 pathway and regulatory T cells (Treg) are essential for the control of immune homeostasis. Their therapeutic relevance is highlighted by the increasing use of anti-CTLA-4 antibody in tumor therapy and the development of Treg cell transfer strategies for use in autoimmunity and transplantation settings. The CTLA-4 pathway first came to the attention of the immunological community...
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ژورنال
عنوان ژورنال: Journal of Autoimmunity
سال: 2013
ISSN: 0896-8411
DOI: 10.1016/j.jaut.2013.06.006